Lipoprotein-associated phospholipase A2 during the hyperacute stage of ischemic and hemorrhagic strokes. - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue Journal of Stroke and Cerebrovascular Diseases Année : 2014

Lipoprotein-associated phospholipase A2 during the hyperacute stage of ischemic and hemorrhagic strokes.

Résumé

The objectives of the study were to compare lipoprotein-associated phospholipase A2 (Lp-PLA2) levels in a prospective cohort including both ischemic and hemorrhagic strokes at the hyperacute phase, and to investigate if these levels were associated with stroke severity. Lp-PLA2 mass and activity were measured during the first 6 hours of symptom onset before any therapeutic intervention. The Lp-PLA2 level was analyzed by comparing the mass and activities in ischemic strokes and spontaneous intracerebral hemorrhages (ICH). Correlations between Lp-PLA2 levels and clinical scores as well as stroke volumes were made. The temporal evolution of Lp-PLA2 during the first week was analyzed in ischemic stroke patients. Lp-PLA2 mass was higher in ICH than in ischemic stroke (P = .001). Lp-PLA2 activity at admission correlated with initial and follow-up stroke volume in ICH (P = .003 and P = .004, respectively) but not in ischemic stroke. None of the measurements correlated with clinical severity for either diagnosis. Lp-PLA2 mass decreased during the first week after the use of statins in ischemic stroke, whereas the activity remained stable. Lp-PLA2 mass is higher in ICH compared with ischemic stroke during the hyperacute stage. Lp-PLA2 activity is associated with stroke volume in ICH but not in ischemic stroke. This suggests that Lp-PLA2 mass and activity could provide different information in the hyperacute stage of stroke.
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Dates et versions

hal-01253339 , version 1 (09-01-2016)

Identifiants

  • HAL Id : hal-01253339 , version 1
  • PUBMED : 24513482

Citer

Charlotte Rosso, David Rosenbaum, Christine Pires, Corinne Cherfils, Nabil Koujah, et al.. Lipoprotein-associated phospholipase A2 during the hyperacute stage of ischemic and hemorrhagic strokes.. Journal of Stroke and Cerebrovascular Diseases, 2014, 23 (4), pp.e277-82. ⟨hal-01253339⟩
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