Cell-kinetics based calibration of a multiscale model: Application to cell population dynamics in ovarian follicles
Résumé
In this paper, we present a strategy for tuning the parameters of a multiscale model of structured cell populations in the physiological context of ovulation. We compute different mesoscopic and macroscopic quantities from the microscopic un-knowns (cell densities) and relate them to experimental cell kinetic indexes. We expose in details the quantitative specifications established from the available biological knowledge. We study the expression of reaching times corresponding to characteristic transitions in a particle-like reduction of the original model. We make use of this framework to obtain an appropriate initial guess for the parameters and then perform a sequence of optimization steps to finally propose a realistic simulation of the cell populations in a cohort of interacting ovarian follicles.