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Communication Dans Un Congrès Année : 2015

Patient-Specific Biomechanical Modeling of Cardiac Amyloidosis – A Case Study

Résumé

We present a patient-specific biomechanical modeling framework and an initial case study for investigating cardiac amyloidosis (CA). Our patient-specific heartbeat simulations are in good agreement with the data, and our model calibration indicates that the major effect of CA in the biophysical behavior lies in a dramatic increase of the passive stiffness. We also conducted a preliminary trial for predicting the effects of pharmacological treatments – which is an important clinical challenge – based on the model combined with a simple venous return representation. This requires further investigation and validation, albeit provides some valuable preliminary insight.
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Dates et versions

hal-01174913 , version 1 (10-07-2015)

Identifiants

Citer

Dominique Chapelle, Alessandro Felder, Radomir Chabiniok, Aziz Guellich, Jean-François Deux, et al.. Patient-Specific Biomechanical Modeling of Cardiac Amyloidosis – A Case Study. Functional Imaging and Modeling of the Heart 2015, Jun 2015, Maastricht, Netherlands. pp.295-303, ⟨10.1007/978-3-319-20309-6_34⟩. ⟨hal-01174913⟩
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