Patient-Specific Biomechanical Modeling of Cardiac Amyloidosis – A Case Study
Résumé
We present a patient-specific biomechanical modeling framework and an initial case study for investigating cardiac amyloidosis (CA). Our patient-specific heartbeat simulations are in good agreement with the data, and our model calibration indicates that the major effect of CA in the biophysical behavior lies in a dramatic increase of the passive stiffness. We also conducted a preliminary trial for predicting the effects of pharmacological treatments – which is an important clinical challenge – based on the model combined with a simple venous return representation. This requires further investigation and validation, albeit provides some valuable preliminary insight.
Domaines
Analyse numérique [math.NA]| Origine | Fichiers produits par l'(les) auteur(s) |
|---|
Loading...