Physical modeling of microtubules network - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Conference Papers Year : 2014

Physical modeling of microtubules network

Abstract

Microtubules (MT) are highly dynamic tubulin polymers that are involved in many cellular processes such as mitosis, intracellular cell organization and vesicular transport. Nevertheless, the modeling of cytoskeleton and MT dynamics based on physical properties is difficult to achieve. Using the Euler-Bernoulli beam theory, we propose to model the rigidity of microtubules on a physical basis using forces, mass and acceleration. In addition, we link microtubules growth and shrinkage to the presence of molecules (e.g. GTP-tubulin) in the cytosol. The overall model enables linking cytosol to microtubules dynamics in a constant state space thus allowing usage of data assimilation techniques.

Dates and versions

hal-01103352 , version 1 (14-01-2015)

Identifiers

Cite

Pierre Allain, Charles Kervrann. Physical modeling of microtubules network. 4th International Workshop on New Computational Methods for Inverse Problems, May 2013, Cachan, France. pp.6, ⟨10.1088/1742-6596/542/1/012005⟩. ⟨hal-01103352⟩

Collections

INRIA INRIA2 ANR
52 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More