Effects of Anti-Angiogenesis on Glioblastoma Growth and Migration: Model to Clinical Predictions - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2014

Effects of Anti-Angiogenesis on Glioblastoma Growth and Migration: Model to Clinical Predictions

Résumé

Glioblastoma multiforme (GBM) causes significant neurological morbidity and short survival times. Brain invasion by GBM is associated with poor prognosis. Recent clinical trials of bevacizumab in newly-diagnosed GBM found no beneficial effects on overall survival times; however, the baseline health-related quality of life and performance status were maintained longer in the bevacizumab group and the glucocorticoid requirement was lower. Here, we construct a clinical-scale model of GBM whose predictions uncover a new pattern of recurrence in 11/70 bevacizumab-treated patients. The findings support an exception to the Folkman hypothesis: GBM grows in the absence of angiogenesis by a cycle of proliferation and brain invasion that expands necrosis. Furthermore, necrosis is positively correlated with brain invasion in 26 newly-diagnosed GBM. The unintuitive results explain the unusual clinical effects of bevacizumab and suggest new hypotheses on the dynamic clinical effects of migration by active transport, a mechanism of hypoxia-driven brain invasion.

Dates et versions

hal-01101651 , version 1 (09-01-2015)

Identifiants

Citer

Elizabeth Scribner, Olivier Saut, Province Paula, Bag Asim, Thierry Colin, et al.. Effects of Anti-Angiogenesis on Glioblastoma Growth and Migration: Model to Clinical Predictions. PLoS ONE, 2014, pp.21. ⟨10.1371/journal.pone.0115018⟩. ⟨hal-01101651⟩
188 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More