Expert-validated CSF segmentation of MNI atlas enhances accuracy of virtual glioma growth patterns - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Journal of Neuro-Oncology Year : 2015

Expert-validated CSF segmentation of MNI atlas enhances accuracy of virtual glioma growth patterns

Abstract

Biomathematical modeling of glioma growth has been de-veloped to optimize treatments delivery and to evaluate their efficacy. Simulations currently make use of anatomical knowledge from standard MRI atlases. For example, cerebrospinal fluid (CSF) spaces are obtained by automatic thresholding of the MNI atlas, leading to an approximate representation of real anatomy. To correct such inaccuracies, an expert-revised CSF segmentation map of the MNI atlas was built. Several virtual glioma growth patterns of different locations were generated, with and without using the expert-revised version of the MNI atlas. The adequacy between virtual and radiologically observed growth patterns was clearly higher when simulations were based on the expert-revised atlas. This work emphasizes the need for close collaboration between clinicians and researchers in the field of brain tumor modeling.

Domains

Medical Imaging
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Dates and versions

hal-01081410 , version 1 (07-11-2014)

Identifiers

Cite

A Amelot, E Stretton, Hervé Delingette, Nicholas Ayache, S Froelich, et al.. Expert-validated CSF segmentation of MNI atlas enhances accuracy of virtual glioma growth patterns. Journal of Neuro-Oncology, 2015, 121 (2), pp.381-387. ⟨10.1007/s11060-014-1645-5⟩. ⟨hal-01081410⟩
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