A Computational Investigation into the Effect of Infarction on Clinical Human Electrophysiology Biomarkers - Inria - Institut national de recherche en sciences et technologies du numérique
Communication Dans Un Congrès Année : 2014

A Computational Investigation into the Effect of Infarction on Clinical Human Electrophysiology Biomarkers

Résumé

The electrocardiogram (ECG) is often used to diag- nose myocardial infarction, but sensitivity and specificity are low. Here we present a computational framework for solving the bidomain equations over an image-based hu- man geometry and simulating the 12 lead ECG. First, we demonstrate this approach by evaluating a population of eight models with varying distributions of local action po- tential duration, and report that only the model with apico- basal and inter-ventricular heterogeneities produces concordant T waves. Second, we simulate the effects of an old anterior infarct, which causes a reduction in T wave amplitude and width. Our methodology can contribute to the understanding of ECG alterations under challenging conditions for clinical diagnosis.
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Dates et versions

hal-01065716 , version 1 (18-09-2014)

Identifiants

  • HAL Id : hal-01065716 , version 1

Citer

Louie Cardone-Noott, Alfonso Bueno-Orovio, Ana Mincholé, Kevin Burrage, Mikael Wallman, et al.. A Computational Investigation into the Effect of Infarction on Clinical Human Electrophysiology Biomarkers. IEEE Computers in Cardiology, Sep 2014, Cambridge, United States. ⟨hal-01065716⟩
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