Thelargesizeofhistologicalimagescombinedwiththeirvery challenging appearance are two main difficulties which considerably com- plicate their analysis. In this paper, we introduce an interactive strategy leveraging the output of a supervised random forest classifier to guide a user through such large visual data. Starting from a forest-based pixel- wise estimate, subregions of the images at hand are automatically ranked and sequentially displayed according to their expected interest. After each region suggestion, the user selects among several options a rough es- timate of the true amount of foreground pixels in this region. From these one-click inputs, the region scoring function is updated in real time using an online gradient descent procedure, which corrects on-the-fly the short- comings of the initial model and adapts future suggestions accordingly. Experimental validation is conducted for extramedullary hematopoesis localization and demonstrates the practical feasibility of the procedure as well as the benefit of the online adaptation strategy.