One key challenge for software product lines is efficiently managing variability throughout their lifecycle. In this paper, we address the problem of variability in software product lines testing. We (1) identify a set of issues that must be addressed to make software product line testing work in practice and (2) provide a framework that combines a set of techniques to solve these issues. The framework integrates feature modelling, combinatorial interaction testing and constraint programming techniques. First, we extract variability in a software product line as a feature model with specified feature interdependencies. We then employ an algorithm that generates a minimal set of valid test cases covering all 2-way feature interactions for a given time interval. Furthermore, we evaluate the framework on an industrial SPL and show that using the framework saves time and provides better test coverage. In particular, our experiments show that the framework improves industrial testing practice in terms of (i) 17% smaller set of test cases that are (a) valid and (b) guarantee all 2-way feature coverage (as opposite to 19.2% 2-way feature coverage in the hand made test set), and (ii) full flexibility and adjustment of test generation to available testing time.