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Journal Articles Theory and Practice of Logic Programming Year : 2013

Minimal Intervention Strategies in Logical Signaling Networks with ASP

Abstract

Proposing relevant perturbations to biological signaling networks is central to many problems in biology and medicine because it allows for enabling or disabling certain biological outcomes. In contrast to quantitative methods that permit fine-grained (kinetic) analysis, qualitative ap- proaches allow for addressing large-scale networks. This is accomplished by more abstract rep- resentations such as logical networks. We elaborate upon such a qualitative approach aiming at the computation of minimal interventions in logical signaling networks relying on Kleene's three- valued logic and fixpoint semantics. We address this problem within answer set programming and show that it greatly outperforms previous work using dedicated algorithms.

Dates and versions

hal-00853747 , version 1 (23-08-2013)

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Roland Kaminski, Anne Siegel, Torsten Schaub, Santiago Videla. Minimal Intervention Strategies in Logical Signaling Networks with ASP. Theory and Practice of Logic Programming, 2013, 29th International Conference on Logic Programming, 13 (Special issue 4-5.), pp.675-690. ⟨10.1017/S1471068413000422⟩. ⟨hal-00853747⟩
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