Binding of intronic miRNAs to the mRNAs of host genes encoding intronic miRNAs and proteins that participate in tumourigenesis
Résumé
In this study, we examined 615 host genes encoding 915 in-miRNAs as possible targets for interactions with all in-miRNAs. Host genes whose proteins are involved in esophageal, gastric, small bowel, colorectal, and breast cancer development were studied. Unique in-miRNA binding sites with a significance of p<0.0005 were found in the 5′UTRs, CDSs, and 3′UTRs of the host genes encoding proteins that are key participants in tumourigenesis. These data shed light on the interactions between miRNAs and mRNAs and on the role of candidate proteins in cancer. Therefore, our findings have potential application in the development of diagnostic and treatment methods.
Dans cette étude, nous avons examiné 615 genes hôtes codant pour 915 in-miRNAs en tant que cibles d'interaction potentielles avec des in-miRNAs.Les protéines de ces gènes hôtes sont impliquées dans le développement de cancers : œsophage, estomac, intestin grêle, colorectal, sein.