Games, in general, have been around since ancient times to entertain us. Since the first electronic and video games appeared in the 1940s and 1950s there has been an increasing demand for enhancements to existing games and new ways of interacting with computer games. Brain/neuronal signal controlled games controllers are now satisfying this demand, extending the accessibility of computer games to physically impaired users and enhancing neurofeedback for rehabilitation and other cognitive problems. Brain-computer interface (BCI) technology for game interactions requires sophisticated signal processing to produce a low communication bandwidth with few degrees of freedom and a relatively inaccurate and unstable control signal. Producing a reliable control signal from non-stationary signals produced by the brain is a challenge being addressed by many researchers. Another challenge is to develop games and games control strategies that can be operated using these unstable and limited control signals and exploit the rich dynamics available in brain/neuronal signals. There remain many challenges to perfecting direct brain gameplay. It is therefore timely to access the state-of-the-art in this field. This special issue presents the latest high quality research and development in brain/neuronal-computer games interfaces and interaction.