Neuronal activity correlated with checking behaviour in the subthalamic nucleus of patients with obsessive-compulsive disorder.
Pierre Burbaud
(1)
,
Anne-Hélène Clair
,
Nicolas Langbour
(2)
,
Sara Fernandez-Vidal
(3, 4)
,
Michel Goillandeau
,
Thomas Michelet
,
Eric Bardinet
(3, 4, 5)
,
Isabelle Chéreau
(6)
,
Franck Durif
(7)
,
Mircea Polosan
(8)
,
Stephan Chabardès
(9)
,
Denys Fontaine
(10)
,
Marie-Noelle Magnié-Mauro
(11)
,
Jean-Luc Houeto
(12, 13)
,
Benoît Bataille
(12)
,
Bruno Millet
(14, 15)
,
Marc Vérin
(16)
,
Nicolas Baup
(17)
,
Marie-Odile Krebs
(17)
,
Philippe Cornu
(18)
,
Antoine Pelissolo
(19)
,
Christophe Arbus
(20)
,
Marion Simonetta-Moreau
(21)
,
Jérôme Yelnik
(3, 22)
,
Marie-Laure Welter
(3, 22, 23)
,
Luc Mallet
(3, 22)
1
PPSC -
Physiologie et physiopathologie de la signalisation cellulaire
2 MAC - Laboratoire Mouvement Adaptation Cognition
3 CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière
4 CENIR - Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris]
5 NEMESIS-CRICM - Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière
6 Service de psychiatrie
7 Service de Neurologie [CHU Clermont-Ferrand]
8 Service de Psychiatrie
9 GIN - Grenoble Institut des Neurosciences
10 Service de Neurochirurgie
11 LPCS - Laboratoire de psychologie cognitive et sociale
12 Service de neurologie [Poitiers]
13 Université de Poitiers
14 Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes]
15 Service de psychiatrie
16 Service de Neurologie [Rennes] = Neurology [Rennes]
17 Service de psychiatrie
18 Service de Neurochirurgie [CHU Pitié-Salpêtrière]
19 Service de psychiatrie adulte [CHU Pitié-Salpêtière]
20 Service Anatomie et cytologie pathologiques [CHU Toulouse]
21 ICHN - Imagerie cérébrale et handicaps neurologiques
22 CIC AP-HP (pitie-Salpetriere)/inserm
23 Service de Neurologie [CHU Pitié-Salpêtrière]
2 MAC - Laboratoire Mouvement Adaptation Cognition
3 CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière
4 CENIR - Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris]
5 NEMESIS-CRICM - Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière
6 Service de psychiatrie
7 Service de Neurologie [CHU Clermont-Ferrand]
8 Service de Psychiatrie
9 GIN - Grenoble Institut des Neurosciences
10 Service de Neurochirurgie
11 LPCS - Laboratoire de psychologie cognitive et sociale
12 Service de neurologie [Poitiers]
13 Université de Poitiers
14 Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes]
15 Service de psychiatrie
16 Service de Neurologie [Rennes] = Neurology [Rennes]
17 Service de psychiatrie
18 Service de Neurochirurgie [CHU Pitié-Salpêtrière]
19 Service de psychiatrie adulte [CHU Pitié-Salpêtière]
20 Service Anatomie et cytologie pathologiques [CHU Toulouse]
21 ICHN - Imagerie cérébrale et handicaps neurologiques
22 CIC AP-HP (pitie-Salpetriere)/inserm
23 Service de Neurologie [CHU Pitié-Salpêtrière]
Anne-Hélène Clair
- Function : Author
Nicolas Langbour
- Function : Author
- PersonId : 751123
- IdHAL : nicolas-langbour
- ORCID : 0000-0001-6779-9484
- IdRef : 167759639
Michel Goillandeau
- Function : Author
- PersonId : 4404
- IdHAL : michel-goillandeau
- IdRef : 253133114
Thomas Michelet
- Function : Author
Marie-Odile Krebs
- Function : Author
- PersonId : 757581
- ORCID : 0000-0002-4715-9890
- IdRef : 069691010
Luc Mallet
- Function : Author
- PersonId : 758746
- ORCID : 0000-0001-8061-1167
- IdRef : 070449864
Abstract
Doubt, and its behavioural correlate, checking, is a normal phenomenon of human cognition that is dramatically exacerbated in obsessive-compulsive disorder. We recently showed that deep brain stimulation in the associative-limbic area of the subthalamic nucleus, a central core of the basal ganglia, improved obsessive-compulsive disorder. To understand the physiological bases of symptoms in such patients, we recorded the activity of individual neurons in the therapeutic target during surgery while subjects performed a cognitive task that gave them the possibility of unrestricted repetitive checking after they had made a choice. We postulated that the activity of neurons in this region could be influenced by doubt and checking behaviour. Among the 63/87 task-related neurons recorded in 10 patients, 60% responded to various combinations of instructions, delay, movement or feedback, thus highlighting their role in the integration of different types of information. In addition, task-related activity directed towards decision-making increased during trials with checking in comparison with those without checking. These results suggest that the associative-limbic subthalamic nucleus plays a role in doubt-related repetitive thoughts. Overall, our results not only provide new insight into the role of the subthalamic nucleus in human cognition but also support the fact that subthalamic nucleus modulation by deep brain stimulation reduced compulsive behaviour in patients with obsessive-compulsive disorder.