Rapid onset frontal leukodystrophy with decreased diffusion coefficient and neuroaxonal spheroids. - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Journal of Neurology Year : 2009

Rapid onset frontal leukodystrophy with decreased diffusion coefficient and neuroaxonal spheroids.

Abstract

Adult leukodystrophies with neuroaxonal spheroids (LNS) constitute a heterogeneous group of genetic diseases. Herein, we report on two unrelated patients with LNS characterized by rapid onset, predominant involvement of the frontal white matter, and areas of decreased apparent diffusion coefficient on diffusion-weighted imaging. We found similar cases in the literature and propose that they represent a distinct entity within the group of LNS. Further studies will be required to identify its molecular basis.

Domains

Medical Imaging

Dates and versions

hal-00805399 , version 1 (27-03-2013)

Identifiers

Cite

Elisabeth Maillart, Audrey Rousseau, Damien Galanaud, Françoise Gray, Marc Polivka, et al.. Rapid onset frontal leukodystrophy with decreased diffusion coefficient and neuroaxonal spheroids.. Journal of Neurology, 2009, 256 (10), pp.1649-54. ⟨10.1007/s00415-009-5172-9⟩. ⟨hal-00805399⟩
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