Qualitative analysis of genetic regulatory networks in bacteria - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Book Sections Year : 2011

Qualitative analysis of genetic regulatory networks in bacteria

Abstract

The adaptation of the bacterium Escherichia coli to carbon starvation is controlled by a large network of biochemical reactions involving genes, mRNAs, proteins, and signalling molecules. The dynamics of this network is difficult to analyze, notably due to a lack of quantitative information on parameter values. To overcome these limitations, the application of model reduction approaches based on QSS and PL approximations may result in models that are easier to handle mathematically and computationally. In particular, PL models allow the analysis of the qualitative dynamics of the network using only weak information on the ordering of parameters rather than their exact numerical values.We illustrate the use of these techniques, implemented in the computer tool Genetic Network Analyzer (GNA), in the case of the E. coli network.
No file

Dates and versions

hal-00793038 , version 1 (21-02-2013)

Identifiers

Cite

Valentina Baldazzi, Pedro T. Monteiro, Michel Page, Delphine Ropers, Hans Geiselmann, et al.. Qualitative analysis of genetic regulatory networks in bacteria. W. Dubitzky and J. Southgate and H. Fuss. Understanding the Dynamics of Biological Systems: Lessons Learned from Integrative Systems Biology, Springer, pp.111-130, 2011, 978-1-4419-7964-3. ⟨10.1007/978-1-4419-7964-3_6⟩. ⟨hal-00793038⟩
245 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More