Modeling lymphocyte homing and encounters in lymph nodes - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles BMC Bioinformatics Year : 2009

Modeling lymphocyte homing and encounters in lymph nodes


The efficiency of lymph nodes depends on tissue structure and organization, which allow the coordination of lymphocyte traffic. Despite their essential role, our understanding of lymph node specific mechanisms is still incomplete and currently a topic of intense research.
In this paper, we present a hybrid discrete/continuous model of the lymph node, accounting for differences in cell velocity and chemotactic response, influenced by the spatial compartmentalization of the lymph node and the regulation of cells migration, encounter, and antigen presentation during the inflammation process.
Our model reproduces the correct timing of an immune response, including the observed time delay between duplication of T helper cells and duplication of B cells in response to antigen exposure. Furthermore, we investigate the consequences of the absence of dendritic cells at different times during infection, and the dependence of system dynamics on the regulation of lymphocyte exit from lymph nodes. In both cases, the model predicts the emergence of an impaired immune response, i.e., the response is significantly reduced in magnitude. Dendritic cell removal is also shown to delay the response time with respect to normal conditions.
Fichier principal
Vignette du fichier
1471-2105-10-387.pdf (876.78 Ko) Télécharger le fichier
1471-2105-10-387.xml (104.82 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other

Dates and versions

hal-00784447 , version 1 (04-02-2013)



Valentina Baldazzi, Paola Paci, Massimo Bernaschi, Filippo Castiglione. Modeling lymphocyte homing and encounters in lymph nodes. BMC Bioinformatics, 2009, 10 (1), pp.387. ⟨10.1186/1471-2105-10-387⟩. ⟨hal-00784447⟩
197 View
264 Download



Gmail Facebook X LinkedIn More