Role of L-type Calcium in Modulating Pro-Arrhythmic Effects of Dofetilide in Human - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Conference Papers Year : 2012

Role of L-type Calcium in Modulating Pro-Arrhythmic Effects of Dofetilide in Human

Abstract

Dofetilide is a class III drug whose use needs to be monitored due to the possible occurrence of Torsades de Pointes (TdP). The mechanisms are unclear but research suggests that both early-afterdepolarizations (EAD) and increased dispersion of action potential duration (APD) might be involved. Importantly, drug-induced TdP is more common in women, possibly due to higher L-type calcium current (ICaL) levels. Our goal is to use numerical simula- tion in order to investigate pro-arrhythmic mechanisms of dofetilide in human by characterizing its effects on APD, APD dispersion and EAD formation for varying doses and ICaL levels.
No file

Dates and versions

hal-00764090 , version 1 (12-12-2012)

Identifiers

  • HAL Id : hal-00764090 , version 1

Cite

Nejib Zemzemi, Javier Saiz Rodriguez, Rodriguez Blanca. Role of L-type Calcium in Modulating Pro-Arrhythmic Effects of Dofetilide in Human. CinC 2012 - Computing in Cardiology, Sep 2012, Krakow, Poland. pp.861-864. ⟨hal-00764090⟩
156 View
0 Download

Share

Gmail Mastodon Facebook X LinkedIn More