A mathematical model of Doxorubicin treatment efficacy for non-Hodgkin's lymphoma: investigation of the current protocol through theoretical modelling results. - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Bulletin of Mathematical Biology Year : 2005

A mathematical model of Doxorubicin treatment efficacy for non-Hodgkin's lymphoma: investigation of the current protocol through theoretical modelling results.

K. Marron
  • Function : Author
Z. Agur
  • Function : Author
T. Alarcón
  • Function : Author
P. K. Maini
  • Function : Author

Abstract

Doxorubicin treatment outcomes for non-Hodgkin's lymphomas (NHL) are mathematically modelled and computationally analyzed. The NHL model includes a tumor structure incorporating mature and immature vessels, vascular structural adaptation and NHL cell-cycle kinetics in addition to Doxorubicin pharmacokinetics (PK) and pharmacodynamics (PD). Simulations provide qualitative estimations of the effect of Doxorubicin on high-grade (HG), intermediate-grade (IG) and low-grade (LG) NHL. Simulation results imply that if the interval between successive drug applications is prolonged beyond a certain point, treatment will be inefficient due to effects caused by heterogeneous blood flow in the system.

Dates and versions

hal-00756368 , version 1 (22-11-2012)

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Benjamin Ribba, K. Marron, Z. Agur, T. Alarcón, P. K. Maini. A mathematical model of Doxorubicin treatment efficacy for non-Hodgkin's lymphoma: investigation of the current protocol through theoretical modelling results.. Bulletin of Mathematical Biology, 2005, 67 (1), pp.79-99. ⟨10.1016/j.bulm.2004.06.007⟩. ⟨hal-00756368⟩
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