Integrating Diverse Reaction Types into Stochastic Models - A Signaling Pathway Case Study in the Imperative Pi-Calculus
Abstract
We present a case study of reusing parameters and reactions of a deterministic model of a biochemical system in order to implement a stochastic one. Our investigations base on a model of the Wnt signaling pathway and aim to study the influence of the cell cycle on the pathway's dynamics. We report on our approaches to solve two major challenges: one is to gather and convert kinetic model parameters, e.g. constants for diffusion and enzymatic reactions. The second challenge is to provide the first implementation of reactions that exhibit Michaelis-Menten kinetics into a pi-calculus based approach by deploying the imperative pi-calculus.
Origin : Files produced by the author(s)
Loading...