This tutorial introduces concepts and approaches related to the integration and interoperability of networked enterprise systems such as enterprise applications (ERP, CRM, SCM, MES ...) and software. It focuses on model-driven engineering frameworks, models transformations and semantics mapping. It also introduces issues and theories related to the specification of shared conceptualizations by defining, formalising and using ontology for semantics mapping when systems interoperate. The main topics that are addressed concern: - Basis of interoperability and enterprise models - Model-driven interoperability: models and models transformations - Location and role of semantics in interoperability approaches