Ca 2+ Flux Through Promiscuous Cardiac Na + Channels: Slip-Mode Conductance - Inria - Institut national de recherche en sciences et technologies du numérique
Article Dans Une Revue Science Année : 1998

Ca 2+ Flux Through Promiscuous Cardiac Na + Channels: Slip-Mode Conductance

L. Santana
  • Fonction : Auteur
Ana Maria Gómez
W. Lederer
  • Fonction : Auteur

Résumé

The tetrodotoxin-sensitive sodium ion (Na + ) channel is opened by cellular depolarization and favors the passage of Na + over other ions. Activation of the β-adrenergic receptor or protein kinase A in rat heart cells transformed this Na + channel into one that is promiscuous with respect to ion selectivity, permitting calcium ions (Ca 2+ ) to permeate as readily as Na + . Similarly, nanomolar concentrations of cardiotonic steroids such as ouabain and digoxin switched the ion selectivity of the Na + channel to this state of promiscuous permeability called slip-mode conductance. Slip-mode conductance of the Na + channel can contribute significantly to local and global cardiac Ca 2+ signaling and may be a general signaling mechanism in excitable cells.
Fichier non déposé

Dates et versions

hal-04409863 , version 1 (22-01-2024)

Identifiants

Citer

L. Santana, Ana Maria Gómez, W. Lederer. Ca 2+ Flux Through Promiscuous Cardiac Na + Channels: Slip-Mode Conductance. Science, 1998, 279 (5353), pp.1027-1033. ⟨10.1126/science.279.5353.1027⟩. ⟨hal-04409863⟩
2 Consultations
0 Téléchargements

Altmetric

Partager

More