Association between nebuliser therapies adherence and visit-to-visit variability of FEV1 in patients with cystic fibrosis - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Journal of Cystic Fibrosis Year : 2023

Association between nebuliser therapies adherence and visit-to-visit variability of FEV1 in patients with cystic fibrosis

Abstract

At the same level of lung function, some patients with cystic fibrosis have large variations in their FEV1 percent predicted (FEV1pp) values while others have stable values. We hypothesised that lower adherence to nebuliser therapies was associated with higher FEV1pp variability. We conducted a post hoc analysis of the ACtiF trial data. Adherence was calculated using data from data-logging nebulisers, and FEV1pp variability using the coefficient of variation equation. Amongst the 543 patients included in the analysis, those poorly adherent (adherence < 50%) had a higher FEV1pp variability than patients moderately (50 to < 80%) and highly adherent (≥ 80%), with median values (IQR1–3) of 8.1% (4.9–13.7), 6.3% (3.9–9.8), and 6.3% (3.9–9.3) respectively (p < 0.01). This result was confirmed by a multiple linear regression including adherence as a continuous variable (p < 0.01). Further studies are needed to determine the implications of these differences in FEV1pp variability on the prognosis of patients.
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Dates and versions

hal-04339233 , version 1 (12-12-2023)

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David Drummond, Pauline Whelan, Matthew Sperrin. Association between nebuliser therapies adherence and visit-to-visit variability of FEV1 in patients with cystic fibrosis. Journal of Cystic Fibrosis, 2023, 22 (4), pp.702-705. ⟨10.1016/j.jcf.2023.03.006⟩. ⟨hal-04339233⟩
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