Unlabelled - The simultaneous or sequential occurrence of several hazards-be they of natural or anthropogenic sources-can interact to produce unexpected hazards and impacts. Since success in responding to volcanic crises is often conditional on accurate identification of spatiotemporal patterns of hazard prior to an eruption, ignoring these interactions can lead to a misrepresentation or misinterpretation of the risk and, during emergencies, ineffective management priorities. The 2021 eruption of Tajogaite volcano on the island of La Palma, Canary Islands (Spain), was an 86 day-long hybrid explosive-effusive eruption that demonstrated the challenges of managing volcanic crises associated with the simultaneous emission of lava, tephra and volcanic gases. Here, we present the result of a small-scale impact assessment conducted during three-field deployments to investigate how tephra fallout and lava flow inundation interacted to cause compound physical impact on buildings. The study area was a neighbourhood of 30 buildings exposed to tephra fallout during the entire eruption and by a late-stage, short-lived lava flow. Observations highlight, on one hand, the influence of clean-up operations and rainfall on the impact of tephra fallout and, on the other hand, the importance of the dynamics of lava flow emplacement in controlling impact mechanisms. Overall, results provide an evidence-based insight into impact sequences when two primary hazards are produced simultaneously and demonstrate the importance of considering this aspect when implementing risk mitigation strategies for future long-lasting, hybrid explosive-effusive eruptions in urban environments. Supplementary information - The online version contains supplementary material available at 10.1007/s00445-023-01700-w.