Fiber crosslinking drives the emergence of order in a 3D dynamical network model - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Royal Society Open Science Year : 2024

Fiber crosslinking drives the emergence of order in a 3D dynamical network model

Abstract

The Extra-Cellular-Matrix (ECM) is a complex interconnected 3D network that provides structural support for the cells and tissues and defines organ architecture key for their healthy functioning. However, the intimate mechanisms by which ECM acquire their 3D architecture are still largely unknown. In this paper, we address this question by means of a 3D individual based model of interacting fibers able to spontaneously crosslink or unlink to each other and align at the crosslinks. We show that such systems are able to spontaneously generate different types of architectures. We provide a thorough analysis of the emerging structures by an exhaustive parametric analysis and the use of appropriate visualization tools and quantifiers in 3D. The most striking result is that the emergence of ordered structures can be fully explained by a single emerging variable : the proportion of crosslinks in the network. This simple variable becomes an important putative target to control and predict the structuring of biological tissues, to suggest possible new therapeutic strategies to restore tissue functions after disruption, and to help in the development of collagen-based scaffolds for tissue engineering. Moreover, the model reveals that the emergence of architecture is a spatially homogeneous process following a unique evolutionary path, and highlights the essential role of dynamical crosslinking in tissue structuring.
Fichier principal
Vignette du fichier
main_v8.pdf (16.05 Mo) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-04168503 , version 1 (21-07-2023)
hal-04168503 , version 2 (27-09-2023)

Identifiers

  • HAL Id : hal-04168503 , version 2

Cite

Pauline Chassonnery, Jenny Paupert, Anne Lorsignol, Childérick Séverac, Marielle Ousset, et al.. Fiber crosslinking drives the emergence of order in a 3D dynamical network model. Royal Society Open Science, 2024, 11, pp.231456. ⟨hal-04168503v2⟩
78 View
11 Download

Share

Gmail Mastodon Facebook X LinkedIn More