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Journal Articles Human Vaccines & Immunotherapeutics Year : 2022

Update about Oralair® as a treatment for grass pollen allergic rhinitis

Ralph Mösges
de Yun Wang
Robyn E. O’hehir
Catherine Bos
Efstrathios Karagiannis


Sublingual immunotherapy (SLIT) is a well-tolerated, safe, and effective approach to treating allergic rhinitis (AR). Oralair® is a five-grass pollen SLIT tablet containing natural pollen allergens from five of the major grass species responsible for seasonal AR due to grass pollen allergy. Recommended use is in a pre-coseasonal regimen, starting daily treatment approximately 4 months before the start of the pollen season, with treatment then continued daily throughout the season; treatment should continue for 3-5 y. Clinical efficacy and safety of Oralair® in patients with grass pollen-induced AR has been demonstrated in a comprehensive clinical development program of randomized controlled trials. Effectiveness has been substantiated in subsequent observational studies with sustained efficacy following treatment cessation and a favorable level of adherence, quality of life, benefit, and satisfaction for the patients. Supportive evidence for a benefit in reducing the risk or delaying the development of allergic asthma is emerging.
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hal-03935968 , version 1 (12-01-2023)


Attribution - NonCommercial - NoDerivatives



Ludger Klimek, Randolf Brehler, Ralph Mösges, P. Demoly, Joaquim Mullol, et al.. Update about Oralair® as a treatment for grass pollen allergic rhinitis. Human Vaccines & Immunotherapeutics, 2022, 18 (5), pp.e2066424. ⟨10.1080/21645515.2022.2066424⟩. ⟨hal-03935968⟩
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