COVID-19 pandemic-associated chilblains: more links for SARS-CoV-2 and less evidence for high interferon type I systemic response - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles British Journal of Dermatology Year : 2022

COVID-19 pandemic-associated chilblains: more links for SARS-CoV-2 and less evidence for high interferon type I systemic response

Valérie Pallure
  • Function : Author

Abstract

Since the onset of the SARS‐CoV‐2 pandemic, the direct causative role of the virus in COVID‐19‐associated chilblains (CAC) has remained under question due to the low rate of positivity to SARS‐CoV‐2 nasopharyngeal polymerase chain reaction (PCR) and blood serology.1 Likewise, the suspected pivotal pathogenic role of upregulation of interferon type I (IFN‐I) is mainly indirectly supported by assessment of in situ immune response.2 From April 2020 to January 2022, we prospectively assessed children and adults with new‐onset CAC seen in the dermatology, infectious diseases, and adult and paediatric emergency departments, as well as the intensive care unit of the University Hospital of Montpellier. The study was approved by the local institutional review board (ID: 202000442).
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Dates and versions

hal-03930679 , version 1 (03-10-2023)

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Didier Bessis, Sophie Trouillet‐Assant, Léo‐Paul Secco, Nathalie Bardin, Brigitte Blanc, et al.. COVID-19 pandemic-associated chilblains: more links for SARS-CoV-2 and less evidence for high interferon type I systemic response. British Journal of Dermatology, 2022, 187 (6), pp.1032-1035. ⟨10.1111/bjd.21820⟩. ⟨hal-03930679⟩
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