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Journal Articles npj Digital Medicine Year : 2022

International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality

Griffin Weber (1) , Chuan Hong (1) , Zongqi Xia (2) , Nathan Palmer (1) , Paul Avillach (1) , Sehi L’yi (1) , Mark Keller (1) , Shawn Murphy (3) , Alba Gutiérrez-Sacristán (1) , Clara-Lea Bonzel (1) , Arnaud Serret-Larmande (4, 5) , Antoine Neuraz (6, 7, 5) , Gilbert Omenn (8) , Shyam Visweswaran (2) , Jeffrey Klann (3) , Andrew South (9) , Ne Hooi Will Loh (10) , Mario Cannataro (11) , Brett Beaulieu-Jones (1) , Riccardo Bellazzi (12, 13) , Giuseppe Agapito (11) , Mario Alessiani (14) , Bruce Aronow (15) , Douglas Bell (16) , Vincent Benoit (17) , Florence Bourgeois (1) , Luca Chiovato (13) , Kelly Cho (18) , Arianna Dagliati (12) , Scott Duvall , Noelia García Barrio (19) , David Hanauer (8) , Yuk-Lam Ho (18) , John Holmes (20) , Richard Issitt (21) , Molei Liu (22) , Yuan Luo (23) , Kristine Lynch (24) , Sarah Maidlow (8) , Alberto Malovini (13) , Kenneth Mandl (25) , Chengsheng Mao (23) , Michael Matheny , Jason Moore (20) , Jeffrey Morris (20) , Michele Morris (2) , Danielle Mowery (20) , Kee Yuan Ngiam (10) , Lav Patel (26) , Miguel Pedrera Jiménez (19) , Rachel Ramoni , Emily Schriver (20) , Petra Schubert (18) , Pablo Serrano Balazote (19) , Anastasia Spiridou (21) , Amelia Tan (1) , Byorn Tan (27) , Valentina Tibollo (13) , Carlo Torti (11) , Enrico Trecarichi (11) , Xuan Wang (1) , James Aaron , Adem Albayrak , Giuseppe Albi , James Balshi , Anna Alloni , Danilo Amendola , François Angoulvant , Brett Beaulieu-Jones , Li Anthony , Fatima Ashraf , Andrew Atz , Paul Avillach , Paula Azevedo , Antonio Bellasi , Vincent Benoit , Michele Beraghi , José Luis Bernal-Sobrino , Mélodie Bernaux , Romain Bey , Surbhi Bhatnagar , Alvar Blanco-Martínez , Martin Boeker , John Booth , Silvano Bosari , Robert Bradford , Gabriel Brat , Stéphane Bréant , Nicholas Brown , Raffaele Bruno , William Bryant , Mauro Bucalo , Emily Bucholz , Anita Burgun , Tianxi Cai , Aldo Carmona , Charlotte Caucheteux , Julien Champ , Krista Chen , Jin Chen , Lorenzo Chiudinelli , Kelly Cho , James Cimino , Tiago Colicchio , Sylvie Cormont , Sébastien Cossin , Jean Craig , Juan Luis Cruz-Bermúdez , Jaime Cruz-Rojo , Mohamad Daniar , Christel Daniel , Priyam Das , Batsal Devkota , Lana Garmire , Audrey Dionne , Rui Duan , Julien Dubiel , Loic Esteve , Hossein Estiri , Shirley Fan , Robert Follett , Thomas Ganslandt , Noelia García-Barrio , Nils Gehlenborg , Emily Getzen , Alon Geva , Tobias Gradinger , Alexandre Gramfort , Romain Griffier , Nicolas Griffon , Olivier Grisel , Alba Gutiérrez-Sacristán , Larry Han , David Hanauer , Christian Haverkamp , Daniel Key , Derek Hazard , Bing He , Darren Henderson , Martin Hilka , Kenneth Huling , Meghan Hutch , Richard Issitt , Anne Sophie Jannot , Vianney Jouhet , Ramakanth Kavuluru , Chris Kennedy , Kate Kernan , Katie Kirchoff , Jeffrey Klann , Isaac Kohane (1) , Ian Krantz , Detlef Kraska , Ashok Krishnamurthy , Trang Le , Judith Leblanc , Guillaume Lemaitre , Leslie Lenert , Damien Leprovost , Molei Liu , Qi Long , Sara Lozano-Zahonero , Sadiqa Mahmood , Sarah Maidlow , Adeline Makoudjou , Anupama Maram , Patricia Martel , Marcelo Martins , Jayson Marwaha , Aaron Masino , Maria Mazzitelli , Arthur Mensch , Marianna Milano , Marcos Minicucci , Bertrand Moal , Taha Mohseni Ahooyi , Jason Moore , Cinta Moraleda , Jeffrey Morris , Karyn Moshal , Sajad Mousavi , Douglas Murad , Shawn Murphy , Thomas Naughton , Carlos Tadeu Breda Neto , Jane Newburger , Kee Yuan Ngiam , Wanjiku Njoroge , James Norman , Jihad Obeid , Marina Okoshi , Karen Olson , Gilbert Omenn , Nina Orlova , Brian Ostasiewski , Nathan Palmer , Nicolas Paris , Lav Patel , Miguel Pedrera-Jiménez , Ashley Pfaff , Emily Pfaff , Danielle Pillion , Sara Pizzimenti , Hans Prokosch , Robson Prudente , Andrea Prunotto , Víctor Quirós-González , Rachel Ramoni , Maryna Raskin , Siegbert Rieg , Gustavo Roig-Domínguez , Pablo Rojo , Paula Rubio-Mayo , Paolo Sacchi , Carlos Sáez , Elisa Salamanca , Malarkodi Jebathilagam Samayamuthu , L. Nelson Sanchez-Pinto , Arnaud Sandrin , Nandhini Santhanam , Janaina Santos , Fernando Sanz Vidorreta , Maria Savino , Juergen Schuettler , Luigia Scudeller , Neil Sebire , Pablo Serrano-Balazote , Patricia Serre , Arnaud Serret-Larmande , Mohsin Shah , Zahra Shakeri Hossein Abad , Domenick Silvio , Piotr Sliz , Jiyeon Son , Charles Sonday , Andrew South , Francesca Sperotto , Zachary Strasser , Amelia Tan , Bryce Tan , Suzana Tanni , Deanne Taylor , Ana Terriza-Torres , Patric Tippmann , Emma Toh , Yi-Ju Tseng , Andrew Vallejos , Gael Varoquaux , Margaret Vella , Guillaume Verdy , Jill-Jênn Vie , Shyam Visweswaran , Michele Vitacca , Kavishwar Wagholikar , Lemuel Waitman , Demian Wassermann , Griffin Weber , Martin Wolkewitz , Scott Wong , Zongqi Xia , Xin Xiong , Ye Ye , Nadir Yehya , William Yuan , Alberto Zambelli , Harrison Zhang , Daniela Zöller , Valentina Zuccaro , Chiara Zucco , Isaac Kohane , Tianxi Cai (1) , Gabriel Brat (1)
Chuan Hong
Zongqi Xia
Paul Avillach
Sehi L’yi
Mark Keller
Shawn Murphy
Gilbert Omenn
Shyam Visweswaran
Jeffrey Klann
Brett Beaulieu-Jones
Mario Alessiani
  • Function : Author
Bruce Aronow
Douglas Bell
Scott Duvall
  • Function : Author
David Hanauer
Yuk-Lam Ho
Yuan Luo
Sarah Maidlow
Kenneth Mandl
Michael Matheny
  • Function : Author
Danielle Mowery
Lav Patel
Rachel Ramoni
  • Function : Author
Emily Schriver
Petra Schubert
James Aaron
  • Function : Author
Adem Albayrak
  • Function : Author
Giuseppe Albi
  • Function : Author
James Balshi
  • Function : Author
Anna Alloni
  • Function : Author
Danilo Amendola
  • Function : Author
François Angoulvant
Brett Beaulieu-Jones
  • Function : Author
Li Anthony
  • Function : Author
Fatima Ashraf
  • Function : Author
Andrew Atz
  • Function : Author
Paul Avillach
  • Function : Author
Paula Azevedo
  • Function : Author
Antonio Bellasi
  • Function : Author
Vincent Benoit
  • Function : Author
Michele Beraghi
  • Function : Author
José Luis Bernal-Sobrino
  • Function : Author
Mélodie Bernaux
  • Function : Author
Romain Bey
  • Function : Author
Surbhi Bhatnagar
  • Function : Author
Alvar Blanco-Martínez
  • Function : Author
Martin Boeker
  • Function : Author
John Booth
  • Function : Author
Silvano Bosari
  • Function : Author
Robert Bradford
  • Function : Author
Gabriel Brat
  • Function : Author
Stéphane Bréant
  • Function : Author
Nicholas Brown
  • Function : Author
Raffaele Bruno
  • Function : Author
William Bryant
  • Function : Author
Mauro Bucalo
  • Function : Author
Emily Bucholz
  • Function : Author
Anita Burgun
  • Function : Author
Tianxi Cai
  • Function : Author
Aldo Carmona
  • Function : Author
Charlotte Caucheteux
  • Function : Author
Julien Champ
  • Function : Author
Krista Chen
  • Function : Author
Jin Chen
  • Function : Author
Lorenzo Chiudinelli
  • Function : Author
Kelly Cho
  • Function : Author
James Cimino
  • Function : Author
Tiago Colicchio
  • Function : Author
Sylvie Cormont
  • Function : Author
Sébastien Cossin
  • Function : Author
Jean Craig
  • Function : Author
Juan Luis Cruz-Bermúdez
  • Function : Author
Jaime Cruz-Rojo
  • Function : Author
Mohamad Daniar
  • Function : Author
Christel Daniel
  • Function : Author
Priyam Das
  • Function : Author
Batsal Devkota
  • Function : Author
Lana Garmire
  • Function : Author
Audrey Dionne
  • Function : Author
Rui Duan
  • Function : Author
Julien Dubiel
  • Function : Author
Loic Esteve
  • Function : Author
Hossein Estiri
  • Function : Author
Shirley Fan
  • Function : Author
Robert Follett
  • Function : Author
Thomas Ganslandt
  • Function : Author
Noelia García-Barrio
  • Function : Author
Nils Gehlenborg
  • Function : Author
Emily Getzen
  • Function : Author
Alon Geva
  • Function : Author
Tobias Gradinger
  • Function : Author
Alexandre Gramfort
  • Function : Author
Romain Griffier
  • Function : Author
Nicolas Griffon
Olivier Grisel
  • Function : Author
Alba Gutiérrez-Sacristán
  • Function : Author
Larry Han
  • Function : Author
David Hanauer
  • Function : Author
Christian Haverkamp
  • Function : Author
Daniel Key
  • Function : Author
Derek Hazard
  • Function : Author
Bing He
  • Function : Author
Darren Henderson
  • Function : Author
Martin Hilka
  • Function : Author
Kenneth Huling
  • Function : Author
Meghan Hutch
  • Function : Author
Richard Issitt
  • Function : Author
Anne Sophie Jannot
  • Function : Author
Vianney Jouhet
  • Function : Author
Ramakanth Kavuluru
  • Function : Author
Chris Kennedy
  • Function : Author
Kate Kernan
  • Function : Author
Katie Kirchoff
  • Function : Author
Jeffrey Klann
  • Function : Author
Ian Krantz
  • Function : Author
Detlef Kraska
  • Function : Author
Ashok Krishnamurthy
  • Function : Author
Trang Le
  • Function : Author
Judith Leblanc
  • Function : Author
Guillaume Lemaitre
  • Function : Author
Leslie Lenert
  • Function : Author
Damien Leprovost
  • Function : Author
Molei Liu
  • Function : Author
Qi Long
  • Function : Author
Sara Lozano-Zahonero
  • Function : Author
Sadiqa Mahmood
  • Function : Author
Sarah Maidlow
  • Function : Author
Adeline Makoudjou
  • Function : Author
Anupama Maram
  • Function : Author
Patricia Martel
  • Function : Author
Marcelo Martins
  • Function : Author
Jayson Marwaha
  • Function : Author
Aaron Masino
  • Function : Author
Maria Mazzitelli
  • Function : Author
Arthur Mensch
  • Function : Author
Marianna Milano
  • Function : Author
Marcos Minicucci
  • Function : Author
Bertrand Moal
  • Function : Author
Taha Mohseni Ahooyi
  • Function : Author
Jason Moore
  • Function : Author
Cinta Moraleda
  • Function : Author
Jeffrey Morris
  • Function : Author
Karyn Moshal
  • Function : Author
Sajad Mousavi
  • Function : Author
Douglas Murad
  • Function : Author
Shawn Murphy
  • Function : Author
Thomas Naughton
  • Function : Author
Carlos Tadeu Breda Neto
  • Function : Author
Jane Newburger
  • Function : Author
Kee Yuan Ngiam
  • Function : Author
Wanjiku Njoroge
  • Function : Author
James Norman
  • Function : Author
Jihad Obeid
  • Function : Author
Marina Okoshi
  • Function : Author
Karen Olson
  • Function : Author
Gilbert Omenn
  • Function : Author
Nina Orlova
  • Function : Author
Brian Ostasiewski
  • Function : Author
Nathan Palmer
  • Function : Author
Nicolas Paris
  • Function : Author
Lav Patel
  • Function : Author
Miguel Pedrera-Jiménez
  • Function : Author
Ashley Pfaff
  • Function : Author
Emily Pfaff
  • Function : Author
Danielle Pillion
  • Function : Author
Sara Pizzimenti
  • Function : Author
Hans Prokosch
  • Function : Author
Robson Prudente
  • Function : Author
Andrea Prunotto
  • Function : Author
Víctor Quirós-González
  • Function : Author
Rachel Ramoni
  • Function : Author
Maryna Raskin
  • Function : Author
Siegbert Rieg
  • Function : Author
Gustavo Roig-Domínguez
  • Function : Author
Pablo Rojo
  • Function : Author
Paula Rubio-Mayo
  • Function : Author
Paolo Sacchi
  • Function : Author
Carlos Sáez
  • Function : Author
Elisa Salamanca
  • Function : Author
L. Nelson Sanchez-Pinto
  • Function : Author
Arnaud Sandrin
  • Function : Author
Nandhini Santhanam
  • Function : Author
Janaina Santos
  • Function : Author
Fernando Sanz Vidorreta
  • Function : Author
Maria Savino
  • Function : Author
Juergen Schuettler
  • Function : Author
Luigia Scudeller
  • Function : Author
Neil Sebire
  • Function : Author
Pablo Serrano-Balazote
  • Function : Author
Patricia Serre
  • Function : Author
Arnaud Serret-Larmande
  • Function : Author
Mohsin Shah
  • Function : Author
Zahra Shakeri Hossein Abad
  • Function : Author
Domenick Silvio
  • Function : Author
Piotr Sliz
  • Function : Author
Jiyeon Son
  • Function : Author
Charles Sonday
  • Function : Author
Andrew South
  • Function : Author
Francesca Sperotto
  • Function : Author
Zachary Strasser
  • Function : Author
Amelia Tan
Bryce Tan
  • Function : Author
Suzana Tanni
  • Function : Author
Deanne Taylor
  • Function : Author
Ana Terriza-Torres
  • Function : Author
Patric Tippmann
  • Function : Author
Emma Toh
  • Function : Author
Yi-Ju Tseng
  • Function : Author
Andrew Vallejos
  • Function : Author
Gael Varoquaux
  • Function : Author
Margaret Vella
  • Function : Author
Guillaume Verdy
  • Function : Author
Jill-Jênn Vie
  • Function : Author
Shyam Visweswaran
  • Function : Author
Michele Vitacca
  • Function : Author
Kavishwar Wagholikar
  • Function : Author
Lemuel Waitman
  • Function : Author
Demian Wassermann
  • Function : Author
Griffin Weber
  • Function : Author
Martin Wolkewitz
  • Function : Author
Scott Wong
  • Function : Author
Zongqi Xia
  • Function : Author
Xin Xiong
  • Function : Author
Ye Ye
  • Function : Author
Nadir Yehya
  • Function : Author
William Yuan
  • Function : Author
Alberto Zambelli
  • Function : Author
Harrison Zhang
  • Function : Author
Daniela Zöller
  • Function : Author
Valentina Zuccaro
  • Function : Author
Chiara Zucco
  • Function : Author
Isaac Kohane
Tianxi Cai
Gabriel Brat

Abstract

Abstract Given the growing number of prediction algorithms developed to predict COVID-19 mortality, we evaluated the transportability of a mortality prediction algorithm using a multi-national network of healthcare systems. We predicted COVID-19 mortality using baseline commonly measured laboratory values and standard demographic and clinical covariates across healthcare systems, countries, and continents. Specifically, we trained a Cox regression model with nine measured laboratory test values, standard demographics at admission, and comorbidity burden pre-admission. These models were compared at site, country, and continent level. Of the 39,969 hospitalized patients with COVID-19 (68.6% male), 5717 (14.3%) died. In the Cox model, age, albumin, AST, creatine, CRP, and white blood cell count are most predictive of mortality. The baseline covariates are more predictive of mortality during the early days of COVID-19 hospitalization. Models trained at healthcare systems with larger cohort size largely retain good transportability performance when porting to different sites. The combination of routine laboratory test values at admission along with basic demographic features can predict mortality in patients hospitalized with COVID-19. Importantly, this potentially deployable model differs from prior work by demonstrating not only consistent performance but also reliable transportability across healthcare systems in the US and Europe, highlighting the generalizability of this model and the overall approach.

Dates and versions

hal-03886991 , version 1 (06-12-2022)

Identifiers

Cite

Griffin Weber, Chuan Hong, Zongqi Xia, Nathan Palmer, Paul Avillach, et al.. International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality. npj Digital Medicine, 2022, 5 (1), pp.74. ⟨10.1038/s41746-022-00601-0⟩. ⟨hal-03886991⟩
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