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Journal Articles Critical Care Year : 2022

Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

1 MASCOT (UMR_S_942 / U942) - Marqueurs cardiovasculaires en situation de stress
2 Cardiovascular & Renal Clinical Trialists - CRCT - French-Clinical Research Infrastructure Network - F-CRIN [Paris]
3 Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal
4 Vanderbilt University School of Medicine [Nashville]
5 PREMEDICAL - Médecine de précision par intégration de données et inférence causale
6 IDESP - Institut Desbrest de santé publique
7 IThEM - U1140 - Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis
8 HEGP - Hôpital Européen Georges Pompidou [APHP]
9 Nantes Univ - Nantes Université
10 CHU Nantes - Centre Hospitalier Universitaire de Nantes
11 MRI - Momentum Research Inc. [Durham, NC, USA]
12 Hôpital Beaujon [AP-HP]
13 UPCité - Université Paris Cité
14 CIC - Centre d'investigation clinique [Nancy]
15 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
16 INI-CRCT - Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]
17 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
18 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
19 HUPS - Hôpitaux Universitaires Paris Sud [AP-HP]
20 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
21 CHRU Montpellier - Hôpital Saint Eloi
22 CHU Angers - Centre Hospitalier Universitaire d'Angers
23 UA - Université d'Angers
24 CRI (UMR_S_1149 / ERL_8252 / U1149) - Centre de recherche sur l'Inflammation
25 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
26 Cliniques universitaires St Luc [Bruxelles]
27 LVTS (UMR_S_1148 / U1148) - Laboratoire de Recherche Vasculaire Translationnelle

Abstract

Background Impact of in-ICU transfusion on long-term outcomes remains unknown. The purpose of this study was to assess in critical-care survivors the association between in-ICU red blood cells transfusion and 1-year mortality. Methods FROG-ICU, a multicenter European study enrolling all-comers critical care patients was analyzed ( n = 1551). Association between red blood cells transfusion administered in intensive care unit and 1-year mortality in critical care survivors was analyzed using an augmented inverse probability of treatment weighting-augmented inverse probability of censoring weighting method to control confounders. Results Among the 1551 ICU-survivors, 42% received at least one unit of red blood cells while in intensive care unit. Patients in the transfusion group had greater severity scores than those in the no-transfusion group. According to unweighted analysis, 1-year post-critical care mortality was greater in the transfusion group compared to the no-transfusion group (hazard ratio (HR) 1.78, 95% CI 1.45–2.16). Weighted analyses including 40 confounders, showed that transfusion remained associated with a higher risk of long-term mortality (HR 1.21, 95% CI 1.06–1.46). Conclusions Our results suggest a high incidence of in-ICU RBC transfusion and that in-ICU transfusion is associated with a higher 1-year mortality among in-ICU survivors. Trial registration ( NCT01367093 ; Registered 6 June 2011). Graphic Abstract
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Dates and versions

hal-03806977 , version 1 (08-10-2022)

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Alice Blet, Joel Mcneil, Julie Josse, Bernard Cholley, Raphaël Cinotti, et al.. Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors. Critical Care, 2022, 26 (1), pp.307. ⟨10.1186/s13054-022-04171-1⟩. ⟨hal-03806977⟩
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