Long-range promoter–enhancer contacts are conserved during evolution and contribute to gene expression robustness - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Genome Research Year : 2022

Long-range promoter–enhancer contacts are conserved during evolution and contribute to gene expression robustness

Abstract

Gene expression is regulated through complex molecular interactions, involving cis -acting elements that can be situated far away from their target genes. Data on long-range contacts between promoters and regulatory elements are rapidly accumulating. However, it remains unclear how these regulatory relationships evolve and how they contribute to the establishment of robust gene expression profiles. Here, we address these questions by comparing genome-wide maps of promoter-centered chromatin contacts in mouse and human. We show that there is significant evolutionary conservation of cis -regulatory landscapes, indicating that selective pressures act to preserve not only regulatory element sequences but also their chromatin contacts with target genes. The extent of evolutionary conservation is remarkable for long-range promoter–enhancer contacts, illustrating how the structure of regulatory landscapes constrains large-scale genome evolution. We show that the evolution of cis -regulatory landscapes, measured in terms of distal element sequences, synteny, or contacts with target genes, is significantly associated with gene expression evolution.
Fichier principal
Vignette du fichier
Laverre2022.full.pdf (544.76 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03559410 , version 1 (10-11-2022)

Identifiers

Cite

Alexandre Laverré, Eric Tannier, Anamaria Necsulea. Long-range promoter–enhancer contacts are conserved during evolution and contribute to gene expression robustness. Genome Research, 2022, 32 (2), pp.280-296. ⟨10.1101/gr.275901.121⟩. ⟨hal-03559410⟩
159 View
22 Download

Altmetric

Share

Gmail Facebook X LinkedIn More