A Tale of a Two Waves Epidemic: Characteristics and Mortality Risk Factors for COVID-19 ICU Patients in the French West Indies - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Journal of Biology and Today's World Year : 2021

A Tale of a Two Waves Epidemic: Characteristics and Mortality Risk Factors for COVID-19 ICU Patients in the French West Indies

Jean-David Pommier
  • Function : Author
Frederic Martino
  • Function : Author
Laure Flurin
  • Function : Author
Fabien Van Roy
  • Function : Author
Michel Carles
Marc Valette
  • Function : Author
Laurent Camous

Abstract

Introduction: Guadeloupe, a French West Indies island, has been fiercely affected by two large waves of COVID.Therapeutic approach was different between the two waves in the intensive care unit (ICU). We aimed to compare the two different periods in terms of characteristics and outcomes and to evaluate risk factors associated with 60-day mortality in our overall cohort. Methods: All consecutive patients with laboratory confirmed COVID-19 pneumonia and requiring oxygen support admitted in our ICU unit of University Hospital of Guadeloupe were prospectively included. Patients were treated during the first wave with a combination of Hydroxychloroquine and Azithromycin and during the second wave with dexamethasone and reinforced anticoagulation. Results: In our cohort, 187 patients were included, 31 during the first one and 156 during the second. Patients were mostly male (69%) with a median age of 64years old. Patients tend to be younger during the second wave and body mass index was higher (respectively 31 vs 27kg/m2, p=0.01). Overall mortality at Day 60 was high (45%) and not different between the two waves. Among patients under mechanical ventilation risk factors associated with death in a multivariate analysis were a high number of comorbidities, a high level of SOFA score and the delay of invasive mechanical ventilation (IMV) onset after admission in ICU (OR=1.6 (95% CI 1.2 – 2.4). Conclusion: Although therapeutics approach evolve, COVID-19 severe pneumonia is still associated with a high mortality rate in ICU.

Dates and versions

hal-03536693 , version 1 (20-01-2022)

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Jean-David Pommier, Frederic Martino, Kevin Bleakley, Laure Flurin, Fabien Van Roy, et al.. A Tale of a Two Waves Epidemic: Characteristics and Mortality Risk Factors for COVID-19 ICU Patients in the French West Indies. Journal of Biology and Today's World, 2021, ⟨10.21203/rs.3.rs-200243/v1⟩. ⟨hal-03536693⟩
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