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Journal Articles Nature Physics Year : 2024

Spontaneous rotations in epithelia as an interplay between cell polarity and boundaries

Abstract

Directed flows of cells in vivo are essential in morphogenesis. They shape living matter in phenomena involving cell mechanics and regulations of the acto-myosin cytoskeleton. However the onset of coherent motion during collective cell migration is still poorly understood. Here we show that coherence is set by spontaneous alignments of cell polarity by designing cellular rings of controlled dimensions. A tug-of-war between opposite polarities dictates the onset of coherence, as assessed by tracking live cellular shapes and motions in various experimental conditions. In addition, we identify an internally driven constraint by cellular acto-myosin cables at boundaries as essential to ensure coherence and active force is generated as evaluated by the high RhoA activity. Its contribution is required to trigger coherence as shown by our numerical simulations based on a novel Vicsek-type model including free active boundaries. Altogether, spontaneous coherent motion results from basic interplay between cell orientations and active cables at boundaries.
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Dates and versions

hal-03427805 , version 1 (14-11-2023)

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Simon Lo Vecchio, Olivier Pertz, Marcela Szopos, Laurent Navoret, Daniel Riveline. Spontaneous rotations in epithelia as an interplay between cell polarity and boundaries. Nature Physics, 2024, ⟨10.1038/s41567-023-02295-x⟩. ⟨hal-03427805⟩
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