New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Sensors Year : 2021

New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses

Abstract

Peripheral Nerve Stimulation (PNS) is a promising approach in functional restoration following neural impairments. Although it proves to be advantageous in the number of implantation sites provided compared with intramuscular or epimysial stimulation and the fact that it does not require daily placement, as is the case with surface electrodes, the further advancement of PNS paradigms is hampered by the limitation of spatial selectivity due to the current spread and variations of nerve physiology. New electrode designs such as the Transverse Intrafascicular Multichannel Electrode (TIME) were proposed to resolve this issue, but their use was limited by a lack of innovative multichannel stimulation devices. In this study, we introduce a new portable multichannel stimulator-called STIMEP-and implement different stimulation protocols in rats to test its versatility and unveil the potential of its combined use with TIME electrodes in rehabilitation protocols. We developed and tested various stimulation paradigms in a single fascicle and thereafter implanted two TIMEs. We also tested its stimulation using two different waveforms. The results highlighted the versatility of this new stimulation device and advocated for the parameterizing of a hyperpolarizing phase before depolarization as well as the use of small pulse widths when stimulating with multiple electrodes.
Fichier principal
Vignette du fichier
Guiho_et_al_sensors.pdf (4.03 Mo) Télécharger le fichier
Origin Publication funded by an institution

Dates and versions

hal-03409467 , version 1 (29-10-2021)

Licence

Identifiers

Cite

Thomas Guiho, Victor Manuel López-Álvarez, Paul Čvančara, Arthur Hiairrassary, David Andreu, et al.. New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses. Sensors, 2021, 21, pp.#7219. ⟨10.3390/s21217219⟩. ⟨hal-03409467⟩
45 View
141 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More