Patient-Specific Modelling of Blood Coagulation - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Bulletin of Mathematical Biology Year : 2021

Patient-Specific Modelling of Blood Coagulation

Abstract

Blood coagulation represents one of the most studied processes in biomedical modelling. However, clinical applications of this modelling remain limited because of the complexity of this process and because of large inter-patient variation of the concentrations of blood factors, kinetic constants and physiological conditions. Determination of some of these patients-specific parameters is experimentally possible, but it would be related to excessive time and material costs impossible in clinical practice. We propose in this work a methodological approach to patient-specific modelling of blood coagulation. It begins with conventional thrombin generation tests allowing the determination of parameters of a reduced kinetic model. Next, this model is used to study spatial distributions of blood factors and blood coagulation in flow, and to evaluate the results of medical treatment of blood coagulation disorders.
Fichier principal
Vignette du fichier
BMB-2021.pdf (2.05 Mo) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-03386476 , version 1 (19-10-2021)

Identifiers

Cite

Nicolas Ratto, Anass Bouchnita, P Chelle, Martine Marion, Mikhail A. Panteleev, et al.. Patient-Specific Modelling of Blood Coagulation. Bulletin of Mathematical Biology, 2021, 83, pp.1-31. ⟨10.1007/s11538-021-00890-8⟩. ⟨hal-03386476⟩
56 View
18 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More