Blood Glucose Regulation in Patients with Type 1 Diabetes Mellitus: A Robust MRAC Approach
Résumé
This paper deals with the problem of robust blood
glucose regulation in critically ill patients affected by type 1
diabetes mellitus. The blood glucose measurement and insulin
infusion are intravenous. The proposed algorithm regulates
blood glucose and keeps it in the normoglycemia range, i.e.,
70–180 mg/dl. To this aim, a control law is proposed based on
a Nonlinear Model Reference Adaptive Control approach. The
algorithm is composed of nonlinear adaptive gains that ensure
convergence to zero of the regulation error.
The approach is validated in the UVA/Padova metabolic
simulator for ten in silico adult patients with unannounced
meals.