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Conference Papers Year : 2021

Distortion of voiced obstruents for differential diagnosis between parkinson's disease and multiple system atrophy

Khalid Daoudi
Biswajit Das
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  • PersonId : 1045821
Solange Milhé de Saint Victor
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Alexandra Foubert-Samier
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Olivier Rascol
Wassilios G Meissner
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Virginie Woisard
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Abstract

Parkinson's disease (PD) and the parkinsonian variant of Multiple System Atrophy (MSA-P) are two neurodegenerative diseases which share similar clinical features, particularly in early disease stages. The differential diagnosis can be thus very challenging. Dysarthria is known to be a frequent and early clinical feature of PD and MSA. It can be thus used as a vehicle to provide a vocal biomarker which could help in the differential diagnosis. In particular, distortion of consonants is known to be a frequent impairment in these diseases. The aim of this study is to investigate distinctive patterns in the distortion of voiced obstruents (plosives and fricatives). It is the first study which attempts to examine such distortions in the French language for the purpose of the differential diagnosis between PD and MSA-P (and among the very few studies if we consider all languages). We carry out a perceptual and objective analysis of voiced obstruents extracted from isolated pseudo-words initials. We first show that devoicing is a significant impairment which predominates in MSA-P. We then show that voice onset time (VOT) of voiced plosives (prevoicing duration) can be a complementary feature to improve the accuracy in discrimination between PD and MSA-P.
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Dates and versions

hal-03313375 , version 1 (03-08-2021)

Identifiers

  • HAL Id : hal-03313375 , version 1

Cite

Khalid Daoudi, Biswajit Das, Solange Milhé de Saint Victor, Alexandra Foubert-Samier, Anne Pavy-Le Traon, et al.. Distortion of voiced obstruents for differential diagnosis between parkinson's disease and multiple system atrophy. INTERSPEECH 2021, Aug 2021, Brno, Czech Republic. ⟨hal-03313375⟩
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