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Conference Papers Year : 2020

A model of apoptosis receptor reactions to study cell fate decision

Abstract

The apoptotic signaling pathway designates a set of biochemical reactions involved in programmed cell death. One of the triggering mechanisms of apoptosis is the binding of death ligands to death receptors on the cell membrane, a known stimulus for the activation of the so-called extrinsic apoptosis signaling pathway. Stimulation by death ligands results in an important variability in cell response dynamics that elicits differing fates: cell survival or cell death. To understand the hallmarks of this cell fate decision and the heterogeneity of cell response, a system of ordinary differential equations based on mass-action rate laws was implemented to represent the reactions at the receptor level and evaluate the cell dynamics in response to anticancer drugs.
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Dates and versions

hal-03021507 , version 1 (24-11-2020)
hal-03021507 , version 2 (12-02-2021)

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Luis Gomes-Pereira, Madalena Chaves, Jérémie Roux. A model of apoptosis receptor reactions to study cell fate decision. MED 2020 - 28th Mediterranean Conference on Control and Automation, Sep 2020, Saint Raphaël, France. pp.887-892, ⟨10.1109/MED48518.2020.9183229⟩. ⟨hal-03021507v2⟩
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