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Journal Articles Trials Year : 2019

Enrolling study personnel in Ebola vaccine trials: from guidelines to practice in a non-epidemic context

Enrolling study personnel in Ebola vaccine trials: from guidelines to practice in a non-epidemic context.

Abstract

Enrolling participants in clinical trials can be challenging, especially with respect to prophylactic vaccine trials. The vaccination of study personnel in Ebola vaccine trials during the 2014-2016 epidemic played a crucial role in inspiring trust and facilitating volunteer enrollment. We evaluated the ethical and methodological considerations as they applied to an ongoing phase 2 randomized prophylactic Ebola vaccine trial that enrolled healthy volunteers in Guinea, Liberia, Sierra Leone, and Mali in a non-epidemic context.

Dates and versions

hal-02426902 , version 1 (02-01-2020)

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Édouard Lhomme, Camara Modet, Augustin Augier, Sylvain Faye, Tienhan Sandrine Dabakuyo-Yonli, et al.. Enrolling study personnel in Ebola vaccine trials: from guidelines to practice in a non-epidemic context. Trials, 2019, 20 (1), pp.422. ⟨10.1186/s13063-019-3487-0⟩. ⟨hal-02426902⟩
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