Enrolling study personnel in Ebola vaccine trials: from guidelines to practice in a non-epidemic context
Enrolling study personnel in Ebola vaccine trials: from guidelines to practice in a non-epidemic context.
Abstract
Enrolling participants in clinical trials can be challenging, especially with respect to prophylactic vaccine trials. The vaccination of study personnel in Ebola vaccine trials during the 2014-2016 epidemic played a crucial role in inspiring trust and facilitating volunteer enrollment. We evaluated the ethical and methodological considerations as they applied to an ongoing phase 2 randomized prophylactic Ebola vaccine trial that enrolled healthy volunteers in Guinea, Liberia, Sierra Leone, and Mali in a non-epidemic context.