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Journal Articles Discrete and Continuous Dynamical Systems - Series S Year : 2019

Modified bidomain model with passive periodic heterogeneities

Abstract

In this paper we study how mesoscopic heterogeneities affect electrical signal propagation in cardiac tissue. The standard model used in cardiac electrophysiology is a bidomain model-a system of degenerate parabolic PDEs, coupled with a set of ODEs, representing the ionic behviour of the cardiac cells. We assume that the heterogeneities in the tissue are periodically distributed diffusive regions, that are significantly larger than a cardiac cell. These regions represent the fibrotic tissue, collagen or fat, that is electrically passive. We give a mathematical setting of the model. Using semigroup theory we prove that such model has a uniformly bounded solution. Finally, we use two-scale convergence to find the limit problem that represents the average behviour of the electrical signal in this setting.
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Dates and versions

hal-02363470 , version 1 (14-11-2019)

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Yves Coudière, Anđela Davidović, Clair Poignard. Modified bidomain model with passive periodic heterogeneities. Discrete and Continuous Dynamical Systems - Series S, 2019, ⟨10.3934/dcdss.2020126⟩. ⟨hal-02363470⟩
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