A Novel Characterization of Traumatic Brain Injury in White Matter with Diffusion MRI Spherical-Harmonics Rotation Invariants
Abstract
The current DTI-based markers of traumatic brain injury are able to capture affected WM in the brain, but missthe areas of crossing fibers and complex WM due to the simplicity of the model. In this work, we use a novelset of spherical-harmonics rotation invariant indices, recently proposed in the literature. We demonstrate thatthese 12 invariants capture all the information provided by DTI. But in addition, they capture differences incomplex WM, beyond DTI measures. This combined with the clinical feasibility of the method, paves the wayfor them to be used as better markers of brain injury.
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