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G protein-coupled receptor-mediated calcium signaling in astrocytes


Astrocytes express a large variety of G protein-coupled receptors (GPCRs) which mediate the transduction of extracellular signals into intracellular calcium responses. This transduc-tion is provided by a complex network of biochemical reactions which mobilizes a wealth of possible calcium-mobilizing second messenger molecules. Inositol 1,4,5-trisphosphate is probably the best known of these molecules whose enzymes for its production and degradation are nonetheless calcium-dependent. We present a biophysical modeling approach based on the assumption of Michaelis-Menten enzyme kinetics, to effectively describe GPCR-mediated astrocytic calcium signals. Our model is then used to study different mechanisms at play in stimulus encoding by shape and frequency of calcium oscillations in astrocytes.
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hal-01995850 , version 1 (27-01-2019)



Maurizio de Pittà, Eshel Ben-Jacob, Hugues Berry. G protein-coupled receptor-mediated calcium signaling in astrocytes. Maurizio De Pittà; Hugues Berry. Computational Glioscience, Springer, pp.115-150, 2019, Springer Series in Computational Neuroscience, 978-3-030-00817-8. ⟨10.1007/978-3-030-00817-8_5⟩. ⟨hal-01995850⟩
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