Multifidelity-CMA: a multifidelity approach for efficient personalisation of 3D cardiac electromechanical models
Résumé
Personalised computational models of the
heart are of increasing interest for clinical applica-
tions due to their discriminative and predictive abili-
ties. However, the simulation of a single heartbeat with
a 3D cardiac electromechanical model can be long and
computationally expensive, which makes some practical
applications, such as the estimation of model parame-
ters from clinical data (the personalisation), very slow.
Here we introduce an original multidelity approach
between a 3D cardiac model and a simplied "0D" ver-
sion of this model, which enables to get reliable (and
extremely fast) approximations of the global behavior
of the 3D model using 0D simulations. We then use
this multidelity approximation to speed-up an ecient
parameter estimation algorithm, leading to a fast and
computationally ecient personalisation method of the
3D model. In particular, we show results on a cohort of
121 dierent heart geometries and measurements. Fi-
nally, an exploitable code of the 0D model with scripts
to perform parameter estimation will be released to the
community.
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