Waste management is one of the significant activities for preserving the environment from pollution that has impact on society mirrored on people’s health. This study approaches the topic of waste management using interpretive qualitative case study method to understand problems in the Municipal Solid Waste Management (MSWM) system in Alexandria city, the second largest city in Egypt. Alexandria has been facing a problematic situation with regard to MSWM, which is worth paying attention to. Furthermore, we explore opportunities for benefiting from Information and Communication Technology (ICT) to improve the MSWM system in Alexandria.