Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Scientific Reports Year : 2017

Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina

Abstract

We have investigated the ontogeny of light-driven responses in mouse retinal ganglion cells (RGCs). Using a large-scale, high-density multielectrode array, we recorded from hundreds to thousands of RGCs simultaneously at pan-retinal level, including dorsal and ventral locations. Responses to di erent contrasts not only revealed a complex developmental pro le for ON, OFF and ON-OFF responses, but also unveiled di erences between dorsal and ventral RGC responses. At eye-opening, dorsal RGCs of all types were more responsive to light, perhaps indicating an environmental priority to nest viewing for pre-weaning pups. The developmental pro le of ON and OFF responses exhibited antagonistic behaviour, with the strongest ON responses shortly after eye-opening, followed by an increase in the strength of OFF responses later on. Further, we found that with maturation receptive eld (RF) center sizes decrease, spike-triggered averaged responses to white noise become stronger, and centers become more circular while maintaining di erences between RGC types. We conclude that the maturation of retinal functionality is not spatially homogeneous, likely re ecting ecological requirements that favour earlier maturation of the dorsal retina.
Fichier principal
Vignette du fichier
2017-hilgen-scientificreport.pdf (2.88 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-01589946 , version 1 (19-09-2017)

Identifiers

  • HAL Id : hal-01589946 , version 1

Cite

Gerrit Hilgen, Sahar Pirmoradian, Daniela Pamplona, Pierre Kornprobst, Bruno Cessac, et al.. Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina. Scientific Reports, 2017, 7. ⟨hal-01589946⟩
132 View
112 Download

Share

Gmail Facebook X LinkedIn More