Preface to Session 70 " Mathematical models and methods to investigate heterogeneity in cell and cell population biology "
Résumé
This session investigates hot topics related to mathematical representations of cell and cell population dynamics in biology and medicine, in particular, but not only, with applications to cancer. Methods in mathematical modelling and analysis, and in statistical inference using single-cell and cell population data, should contribute to focus this session on heterogeneity in cell populations. Among other methods are proposed: a) Intracellular protein dynamics and gene regulatory networks using ordinary/partial/delay differential equations (ODEs, PDEs, DDEs); b) Representation of cell population dynamics using agent-based models (ABMs) and/or PDEs; c) Hybrid models and multiscale models to integrate single-cell dynamics into cell population behaviour; d) Structured cell population dynamics and asymptotic evolution w.r.t. relevant traits; e) Heterogeneity in cancer cell populations: origin, evolution, phylogeny and methods of reconstruction; f) Drug resistance as an evolutionary phenotype: predicting and overcoming it in therapeutics; g) Theoretical therapeutic optimisation of combined drug treatments in cancer cell populations and in populations of other organisms, such as bacteria.
Mots clés
Probabilistic models
Genotype/phenotype evolution
Reaction-diffusion equations
Cell fate decision
Drug tolerance
Single cell/cell population models
Treatment optimisation
Cancer
Immune response
Biofilms
Persisters
Ordinary/partial/delay differential equations
Physiologically structured models
Spatio-temporal dynamics
Agent-based models
Cell population dynamics
Origine | Fichiers produits par l'(les) auteur(s) |
---|
Loading...