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Poster Communications Year : 2015

The effect of retinal GABA Depletion by Allylglycine on mouse retinal ganglion cell responses to light

Abstract

The inhibitory neurotransmitter GABA (γ-aminobutyric acid) is metabolized by glutamic acid decarboxylase (GAD) which exists in two iso- forms in the mature CNS, GAD65 and GAD67. Allylglycine, a glycine derivative, is a nonspecific inhibitor of both GAD isoforms. Prolonged exposure to allylgycine can therefore deplete the tissue of endogenous GABA over time (Orlowski et al, 1977; Chabrol et al., 2012). Here we applied Allylglycine (ALLYL) in vitro over several hours to gradually deplete GABA in the adult mouse retina and compared the effects of GABA depletion on retinal ganglion cells (RGCs) receptive fields with those obtained by simultaneously blocking all GABAergic recep- tors (type A, B and C).
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Dates and versions

hal-01235324 , version 1 (30-11-2015)

Identifiers

  • HAL Id : hal-01235324 , version 1

Cite

Gerrit Hilgen, Samantha Softley, Daniela Pamplona, Pierre Kornprobst, Bruno Cessac, et al.. The effect of retinal GABA Depletion by Allylglycine on mouse retinal ganglion cell responses to light . European Retina Meeting, Oct 2015, Brigthon, United Kingdom. ⟨hal-01235324⟩
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