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Conference Papers Year : 2015

In silico assessment of drugs effects on human embryonic stem cells derived cardiomyocytes electrical activity

Abstract

Computational modeling and simulation is extensively used to investigate diseases in cardiac electrophysiological activity and also drug effects, side effects and interactions. Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have been recently considered as a promising tool in regenerative medicine: their major role in repairing damaged tissue is due to pluripotency and ability to differentiate. These pluripotent cells are also used in early stages of drugs development. Pharmaceutical companies use the MultiElectrode Array (MEA) device in order to perform many in vitro experiments on hESC-CMs. The goal of our study is to derive a mathematical model and to simulate these in vitro experiments.
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Dates and versions

hal-01202019 , version 1 (18-09-2015)

Identifiers

  • HAL Id : hal-01202019 , version 1

Cite

Emanuela Abbate, Nejib Zemzemi, Yves Coudière, Jean-Frédéric Gerbeau. In silico assessment of drugs effects on human embryonic stem cells derived cardiomyocytes electrical activity. LACM 2015 (2nd International Workshop on Latest Advances in Cardiac Modeling), Mar 2015, German Heart Center, Munich, Germany. ⟨hal-01202019⟩
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