Brain-computer interfaces (BCI) can be used as a rehabilitation tool for a subject with disabilities. Their use for compensation of severe motor disabilities has already been evaluated. Here we propose to use a BCI for rehabilitation purposes in the framework of mental handicap caused by schizophrenia. We plan to use serious games for patient rehabilitation through a reduction of associated psychiatric disorders. We focus on the necessity of adapting the BCI to this specific situation and on the importance of involving the patient early in the process, i.e. in the development stage, in order to maximize performance and facilitate future rehabilitation.