Spatial Correlation of Action Potential Duration and Diastolic Dysfunction in Transgenic and Drug-induced LQT2 Rabbits - Inria - Institut national de recherche en sciences et technologies du numérique Access content directly
Journal Articles Heart Rhythm Year : 2013

Spatial Correlation of Action Potential Duration and Diastolic Dysfunction in Transgenic and Drug-induced LQT2 Rabbits

Abstract

Enhanced dispersion of action potential duration (APD) is a major contributor to long-QT-(LQTS)-related arrhythmias.We aimed at investigating spatial correlations of regional heterogeneities in cardiac repolarization and mechanical function in LQTS.Female transgenic LQT2 (n=11) and wildtype (LMC) rabbits (n=9/10 without/with E4031) were subjected to phase contrast MRI to assess regional myocardial velocities. In the same rabbits' hearts, monophasic APDs were assessed in corresponding segments.In LQT2 and E4031 rabbits, APD was longer in all LV segments (p<0.01) and APD dispersion was greater than in LMC (p<0.01). In diastole, peak radial velocities (Vr) were reduced in LQT2 and E4031 compared to LMC in base and mid (cm/s, LQT2, -3.36±0.4, p<0.01, E4031, -3.24±0.6, p<0.0001, LMC, -4.42±0.5) - indicating an impaired diastolic function. Regionally heterogeneous diastolic Vr correlated with APD (LQT2, CC 0.38
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Dates and versions

hal-00855929 , version 1 (30-08-2013)

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Katja E. Odening, Bernd A. Jung, Corinna N. Lang, Rocio Cabrera Lozoya, David Ziupa, et al.. Spatial Correlation of Action Potential Duration and Diastolic Dysfunction in Transgenic and Drug-induced LQT2 Rabbits. Heart Rhythm, 2013, 10 (10), pp.1533-1541. ⟨10.1016/j.hrthm.2013.07.038⟩. ⟨hal-00855929⟩

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