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Journal Articles Acta Biotheoretica Year : 2002

Hyperstructures, genome analysis and I-Cells

Patrick Amar
Pascal Ballet
Georgia Barlovatz-Meimon
  • Function : Author
Gilles Bernot
  • Function : Author
  • PersonId : 1197974
  • IdHAL : bernot
Yves Bouligand
  • Function : Author
François Képès
  • Function : Author
  • PersonId : 1202603
René Natowicz
Paul Soler
  • Function : Author
Philippe Tracqui
  • Function : Author
Olivier Michel


New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology.


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Dates and versions

hal-00827467 , version 1 (29-05-2013)



Patrick Amar, Pascal Ballet, Georgia Barlovatz-Meimon, Arndt Benecke, Gilles Bernot, et al.. Hyperstructures, genome analysis and I-Cells. Acta Biotheoretica, 2002, 50 (4), pp.357-373. ⟨10.1023/A:1022629004589⟩. ⟨hal-00827467⟩
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