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Journal Articles Journal of Mathematical Biology Year : 2015

Discrete limit and monotonicity properties of the Floquet eigenvalue in an age structured cell division cycle model

Abstract

We consider a cell population described by an age-structured partial differential equation with time periodic coefficients. We assume that division only occurs after a minimal age (majority) and within certain time intervals. We study the asymptotic behavior of the dominant Floquet eigenvalue, or Perron-Frobenius eigenvalue, representing the growth rate, as a function of the majority age, when the division rate tends to infinity (divisions become instantaneous). We show that the dominant Floquet eigenvalue converges to a staircase function with an infinite number of steps, determined by a discrete dynamical system. As an intermediate result, we give a structural condition which guarantees that the dominant Floquet eigenvalue is a nondecreasing function of the division rate. We also give a counter example showing that the latter monotonicity property does not hold in general.

Dates and versions

hal-00773211 , version 1 (11-01-2013)

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Stéphane Gaubert, Thomas Lepoutre. Discrete limit and monotonicity properties of the Floquet eigenvalue in an age structured cell division cycle model. Journal of Mathematical Biology, 2015, 71 (6), ⟨10.1007/s00285-015-0874-3⟩. ⟨hal-00773211⟩
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